This truncated myelin oligodendrocyte glycoprotein ( MOG) peptide, was tested to identify the core encephalitogenic epitope of CD8+ MOG-specific T cells, its binding to recombinant H-2Db dimers and the ability to induce experimental autoimmune encephalomyelitis (EAE). This peptide strongly binds recombinant H-2Db protein and this complex bound MOG-specific CD8+ T cells. The minimal, functionally constant MOG peptide that binds to CD8+ MOG-specific T cells and stimulates T cell proliferation in vitro, MOG(4454), is within this sequence.
Ref: Sun, D. et al. Int. Immunol 15, 261(2003)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Arg - Ser - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - OH