Peptides  >  Vasoactive Intestinal Peptides (VIPs)
Vasoactive intestinal polypeptide (VIP) is a member of the vasoactive intestinal peptide/secretin/glucagon family. This anti-inflammatory neuropeptide has an amino acid sequence identity of 68% with pituitary adenylate cyclase-activating polypeptide (PACAP). VIP is broadly distributed in the peripheral and central nervous systems. VIP and PACAP inhibit TNF-a, IL-1, IL-6, and NO production by lipopolysaccharide (LPS)-activated microglia. Both regulate the production of proinflammatory factors at a transcriptional level by inhibiting p65 nuclear translocation and nuclear factor-kB-DNA binding. Vasoactive intestinal peptide plays a role in water transport in the intestines.

Ref: Delgado, M. et al. J. Leukocyte Biol. 73, 155 (2003); Yamamoto, K. et al. Diabetes 52, 1155 (2003); Ganea, D. Cell Mol. Biol. (Noisy-le-grand) 49, 127 (2003); Poso, D. and M. Delgado, FASEB J. 18, 1325 (2004); Romano, D. et al. J. Biol. Chem. 278, 51386 (2003).

 Product Size Catalog # US$  
VIP (1 - 12), human, porcine, rat
1 mg AS-24217 $61
VIP, human, porcine, rat
0.5 mg AS-22872 $71
VIP, human, porcine, rat
1 mg AS-22873 $121
VIP, human, porcine, rat, FAM - labeled
0.5 mg AS-23614 $363
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