Vital Stains for Amyloid Imaging


Vital Stains for Amyloid Imaging

The development of photonic ligands for imaging Aß plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active research topic. When used in combination with positron emission tomography (PET) or single photon emission computed tomography (SPECK), amyloid-imaging tracers can facilitate the evaluation of the efficacy of anti-amyloid therapies. Amyloid-imaging reagents can also serve as surrogate markers in early diagnosis and neuropathogenesis studies of Alzheimer's disease and other aging-related neurodegenerative disorders. The structures of these Aß-imaging reagents vary from large proteins and peptides such as radiolabeled Aß peptides and monoclonal antibodies to small molecules derived from Congo red, Chrysamine-G, thioflavin-T and Acridine Orange. In vitro studies indicate that amyloid plaques contain multiple binding sites that can accommodate structurally diverse compounds, providing flexibility for designing amyloid imaging agents. Compared to large biomolecules, small photonic tracers are often readily accessible through chemical synthesis and can display superior brain permeability. Several small amyloid-imaging photonic ligands display high binding affinities to Aß and sufficient brain penetration for imaging studies. Recent studies demonstrate the feasibility of imaging amyloid plaques in vivo in human subjects with PET.

To help accelerate your ß-amyloid research, AnaSpec offers the following colorimetric and fluorometric imaging reagents for ß-amyloids. These reagents are highly purified and suitable for neurostaining.

To request AnaSpec’s latest Detection Reagents & Kits catalog, click here.

Product Amount Catalog#
BSB
[(trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]
5 mg88300
BTA-1
[2-(4''-(methylamino)phenyl)benzothiazole]
10 mg88301
BTA-2
[2-(4''-(dimethylamino)phenyl)-6-methyl-benzothiazole]
100 mg 88302
Chrysamine G 10 mg 88303
Congo Red *UltraPure Grade*1 g83016
Half Chrysamine G 10 mg 88305
Thioflavin T *UltraPure Grade* 1 g 88306