Peptides  >  Enkephalins
Enkephalins, pentapeptides containing the consensus Tyr-Gly-Gly-Phe-Xaa sequence, are the smallest of the molecules with pain killing or opiate activity. Enkephalins are found in the thalamus of the brain and in some parts of the spinal cord that transmit pain impulses. In the spinal cord, enkephalins inhibit painful sensations by reacting with specific receptor sites on the sensory nerve endings. Nerve endings of the central nervous system (CNS) and the adrenal medulla release these naturally occurring morphine-like substances. Enkephalins bind to opiate receptors and release controlled levels of pain. Leu-enkephalin is an endogenous agonist for the receptors that are stimulated by opiate alkaloids. It has multiple effects on the CNS, including the neuroendocrine hypothalamus. Leu-enkephalin also controls gonadal function. Met-enkephalin is involved in phenomena associated with modulated pain perception, regulation of memory and emotional conditions, food and liquid consumption and regulation of immunological system. It also has an impact on the digestive system motility, gastric as well as in pancreatic secretion and metabolism of carbohydrates.

Ref: Zhang, N. et al. J. Biol. Chem. 278, 12729 (2003); Owczarek, D. et al. Przegl. Lek. 60, 461 (2003); Dudás, B. and I. Merchenthaler et al. J. Clin. Endo. Met. 88, 1842 (2003).
 Product Size Catalog # US$  
[Leu5] - Enkephalin
25 mg AS-24333 $55
[Met5] - Enkephalin
25 mg AS-24334 $66
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