Peptides  >  Substance P and Analogs
Substance P, also known as neurokinin 1, belongs to the tachykinin neuropeptide family and is a neuropeptide that functions as a neurotransmitter and a neuromodulator. It is an 11-amino acid polypeptide with the sequence generated from a glycine-extended precursor protein by endothelin-converting enzyme. In the central nervous system, Substance P is associated with the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, neurotoxicity and pain. In the digestive tract, Substance P, along with some other tachykinins, are neurotransmitters that regulate motor activity, secretion of ions and fluid, as well as vascular functions. In airway sensory nerves, the release of Substance P and nitric oxide modulates airway functions. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R) that belongs to the tachykinin receptor sub-family of GPCRs.

Ref: Leeman, SE. and EA. Mroz, Life Sci. 15, 2033 (1974)); Jeng, A. et al. J. Biol. Chem. 272, 14666 (1997); Wiesenfeld-Hallin, Z. and XJ. Xu, Regul. Pept. 46, 165 (1993).
 Product Size Catalog # US$  
[Succinyl - Asp6, NMePhe8] - Substance P (6 - 11), Senktide
Suc - DF - (NMeF) - GLM - NH2
5 mg AS-22887 $193
Substance P
1 mg AS-24279 $17
Substance P
5 mg AS-24280 $71
Substance P, FAM - labeled
1 mg AS-61201 $225
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