Peptides  >  Luteinizing Hormone-Releasing Hormones and Related Peptides
Luteinizing hormone-releasing hormone (LHRH), also known as Gonadotropin-Releasing Hormone (GnRH) or Luteinizing Hormone-Releasing Factor (LRF), is a hypothalamic neuropeptide which acts on the pituitary to stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH, collectively called gonadotropins, are involved in the control of gonadal steroids, estrogens in female organisms and androgens in male organisms. The effects of LHRH are mediated by high-affinity G protein-coupled LHRH-receptor (LHRH-R) on pituitary gonadotropes. LHRH may act as a growth modulatory factor in tumors of the reproductive system. LHRH and LHRH receptors (LHRH-Rs) are expressed in human melanoma cells and LHRH-Rs are found in greater than 50% of human breast cancers.

Ref: Horvath, J. et al. Proc. Natl. Acad. Sci. USA 99, 15048 (2002); Clayton, RJ. Endocrinol. 120, 11 (1989); Moretti et al. Endocr. Relat. Cancer 10, 161 (2003); Schally, AV. et al. In Infertility and Reproductive Medicine Clinics of North America, ed. Devroey, P. (Saunders, Philadelphia) 12, 17 (2001); Morales et al. Eur. J. Neurosci. 18, 2505 (2003); Green, H. et al. Psychology, Health and Medicine 5, 407 (2000); Williams, G. et al. Prostatic Dis. 6, 187 (2003); Bajo, AM. et al. Clin. Cancer Res. 3742 (2003).
 Product Size Catalog # US$  
Cetrorelix Acetate, Cetrotide 1 mg AS-60869 $181
Luteinizing Hormone - Releasing Hormone (LH - RH), human
25 mg AS-20782 $165
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