Kinase Substrates Peptides

Protein phosphorylation is a major signal transduction mechanism

Protein kinases are a transferase family of self-regulatory enzymes that catalyze the phosphorylation of other proteins by covalently attaching phosphate groups to them, using ATP as a phosphate donor.

Reversible protein phosphorylation-dephosphorylation has a principal role in the regulation of essentially all cellular functions and most aspects of cell life, and phosphorylation by protein kinases is a major signal transduction mechanism that regulates gene expression, proliferation, membrane transport, cell metabolism and many other cellular functions by modifying other proteins.